Table of Contents

ZYMOGENETICS INC filed this Form 8-K on January 7, 2010.

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Entire Document (8-K) PAGE 1. UNITED STATES PAGE 2. Item 1.01 PAGE 3. Item 9.01 PAGE 4. SIGNATURES PAGE 5. EXHIBIT INDEX

Entire Document (EX-1.1) PAGE 1. Exhibit 1.1 PAGE 2. UNDERWRITING AGREEMENT PAGE 3. Representations and Warranties by the Company PAGE 4. bona fide PAGE 5. N/A PAGE 6. N/A PAGE 7. N/A PAGE 8. N/A PAGE 9. N/A PAGE 10. N/A PAGE 11. N/A PAGE 12. N/A PAGE 13. Officer’s Certificates PAGE 14. Denominations; Registration PAGE 15. Delivery of Prospectuses PAGE 16. Reporting Requirements PAGE 17. Expenses PAGE 18. Opinion of Counsel for Underwriters PAGE 19. Additional Documents PAGE 20. Indemnification of Company, Directors and Officers PAGE 21. Settlement without Consent if Failure to Reimburse PAGE 22. Termination; General PAGE 23. N/A PAGE 24. N/A PAGE 25. N/A PAGE 26. Name of Underwriter PAGE 27. N/A PAGE 28. N/A PAGE 29. N/A

Entire Document (EX-5.1) PAGE 1. Exhibit 5.1 PAGE 2. Pricing Committee Resolutions PAGE 3. N/A

Entire Document (EX-99.1) PAGE 1. Exhibit 99.1 PAGE 2. filings with the Securities and Exchange Commission, including its Annual Report on Form 10-K for th